CARs and other T cell therapies for MM: The clinical experience

Danhof S, Hudecek M, Smith EL (2018)

Publication Type: Journal article, Review article

Publication year: 2018

Journal

Best Practice & Research Clinical Haematology Elsevier

Book Volume: 31

Pages Range: 147-157

Journal Issue: 2

DOI: 10.1016/j.beha.2018.03.002

Abstract

Harnessing the endogenous immune system to eliminate malignant cells has long been an intriguing approach. After considerable success in the treatment of B-cell acute lymphoblastic leukemia, chimeric antigen receptor (CAR)-modified T cells have entered early clinical evaluation in the field of multiple myeloma (MM). The choice of suitable non-CD19 target antigens is challenging and a variety of myeloma-associated surface molecules have been under preclinical investigation. Most recent clinical protocols have focused on targeting B-cell maturation antigen (BCMA), and early results are promising. The trials differ in receptor constructs, patient selection, dosing strategies and conditioning chemotherapy and will thus pave the way to eventually define the optimal parameters. Other sources for autologous T-cell therapy of MM include affinity-enhanced T-cell receptor-modified cells and marrow infiltrating lymphocytes. In summary, adoptive T-cell transfer for the treatment of MM is still in its infancy, but if early response rates indicate durability, will be a paradigm changing therapeutic modality for the treatment of MM.

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE) Memorial Sloan Kettering Cancer Center US United States (USA) (US)

How to cite

APA:

Danhof, S., Hudecek, M., & Smith, E.L. (2018). CARs and other T cell therapies for MM: The clinical experience. Best Practice & Research Clinical Haematology, 31(2), 147-157. https://dx.doi.org/10.1016/j.beha.2018.03.002

MLA:

Danhof, Sophia, Michael Hudecek, and Eric L. Smith. "CARs and other T cell therapies for MM: The clinical experience." Best Practice & Research Clinical Haematology 31.2 (2018): 147-157.

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