Protocol for M3P: A comprehensive and clinical oriented targeted sequencing panel for routine molecular analysis in multiple myeloma
Barrio S, Davia M, Bruins L, Stuehmer T, Steinbrunn T, Bittrich M, Einsele H, Stewart AK, Braggio E, Kortuem KM (2018)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2018
Journal
Publisher: Humana Press Inc.
Series: Methods in Molecular Biology
Book Volume: 1792
Pages Range: 117-128
DOI: 10.1007/978-1-4939-7865-6_8
Abstract
Over the past 10 years next generation sequencing (NGS) approaches deciphered a large number of genomes from a wide variety of tumor types. However, despite most relevant findings, this technology has not yet been implemented into standard diagnostic workflows. Broad access to NGS technology is still limited, sequencing/analysis times exceed clinically relevant timeframes and despite huge cuts, costs remain significant. We proposed a custom-tailored gene panel, which focuses on a selected number of relevant genes and developed a clinically oriented NGS targeted sequencing approach for the molecular characterization of Multiple Myeloma (MM) tumors, allowing the description of the tumor genetic heterogeneity and its changes under selective pressure of antitumor therapy, in a more cost effective and faster turnaround timeframe.
Involved external institutions
United States (USA) (US)
Germany (DE)How to cite
APA:
Barrio, S., Davia, M., Bruins, L., Stuehmer, T., Steinbrunn, T., Bittrich, M.,... Kortuem, K.M. (2018). Protocol for M3P: A comprehensive and clinical oriented targeted sequencing panel for routine molecular analysis in multiple myeloma. In (pp. 117-128). Humana Press Inc..
MLA:
Barrio, Santiago, et al. "Protocol for M3P: A comprehensive and clinical oriented targeted sequencing panel for routine molecular analysis in multiple myeloma." Humana Press Inc., 2018. 117-128.
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