Volz J, Mammadova-Bach E, Gil-Pulido J, Nandigama R, Remer K, Sorokin L, Zernecke A, Abrams SI, Erguen S, Henke E, Nieswandt B (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 133
Pages Range: 2696-2706
Journal Issue: 25
Maintenance of tumor vasculature integrity is indispensable for tumor growth and thus affects tumor progression. Previous studies have identified platelets as major regulators of tumor vascular integrity, as their depletion selectively rendered tumor vessels highly permeable and caused massive intratumoral hemorrhage. While these results established platelets as potential targets for antitumor therapy, their depletion is not a treatment option due to their essential role in hemostasis. Thus, a detailed understanding of how platelets safeguard vascular integrity in tumors is urgently demanded. Here, we show for the first time that functional inhibition of glycoprotein VI (GPVI) on the platelet surface with an antibody (JAQ1) F(ab)
APA:
Volz, J., Mammadova-Bach, E., Gil-Pulido, J., Nandigama, R., Remer, K., Sorokin, L.,... Nieswandt, B. (2019). Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice. Blood, 133(25), 2696-2706. https://doi.org/10.1182/blood.2018877043
MLA:
Volz, Julia, et al. "Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice." Blood 133.25 (2019): 2696-2706.
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