Rieckmann M, Delgobo M, Gaal C, Buechner L, Steinau P, Reshef D, Gil-Cruz C, Ter Horst EN, Kircher M, Reiter T, Heinze KG, Niessen HWM, Krijnen PAJ, Van Der Laan AM, Piek JJ, Koch C, Wester HJ, Lapa C, Bauer WR, Ludewig B, Friedman N, Frantz S, Hofmann U, Ramos GC (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 129
Pages Range: 4922-4936
Journal Issue: 11
DOI: 10.1172/JCI123859
T cell autoreactivity is a hallmark of autoimmune diseases but can also benefit self-maintenance and foster tissue repair. Here, we investigated whether heart-specific T cells exert salutary or detrimental effects in the context of myocardial infarction (MI), the leading cause of death worldwide. After screening more than 150 class II–restricted epitopes, we found that myosin heavy chain α (MYHCA) was a dominant cardiac antigen triggering post-MI CD4+ T cell activation in Balb/c mice. Transferred MYHCA
APA:
Rieckmann, M., Delgobo, M., Gaal, C., Buechner, L., Steinau, P., Reshef, D.,... Ramos, G.C. (2019). Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses. Journal of Clinical Investigation, 129(11), 4922-4936. https://doi.org/10.1172/JCI123859
MLA:
Rieckmann, Max, et al. "Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses." Journal of Clinical Investigation 129.11 (2019): 4922-4936.
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