A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves
Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, D'Errico P, Baasch S, Amann L, Masuda T, Loesslein A, Gharun K, Meyer-Luehmann M, Waskow C, Franzke CW, Gruen D, Lammermann T, Prinz M, Henneke P (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 50
Pages Range: 1482-1497.e7
Journal Issue: 6
DOI: 10.1016/j.immuni.2019.05.009
Abstract
The skin comprises tissue macrophages as the most abundant resident immune cell type. Their diverse tasks including resistance against invading pathogens, attraction of bypassing immune cells from vessels, and tissue repair require dynamic specification. Here, we delineated the postnatal development of dermal macrophages and their differentiation into subsets by adapting single-cell transcriptomics, fate mapping, and imaging. Thereby we identified a phenotypically and transcriptionally distinct subset of prenatally seeded dermal macrophages that self-maintained with very low postnatal exchange by hematopoietic stem cells. These macrophages specifically interacted with sensory nerves and surveilled and trimmed the myelin sheath. Overall, resident dermal macrophages contributed to axon sprouting after mechanical injury. In summary, our data show long-lasting functional specification of macrophages in the dermis that is driven by stepwise adaptation to guiding structures and ensures codevelopment of ontogenetically distinct cells within the same compartment. Macrophages perform a wide variety of functions in mammalian tissues. Kolter and colleagues provide a map of dermal macrophages in mouse skin and identify a subset of embryonic macrophages that populates sensory nerve fibers. These self-maintaining macrophages actively patrol axons and promote nerve regeneration upon tissue damage.
Involved external institutions
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Technische Universität Dresden
Germany (DE)
Max-Planck-Institut für Immunbiologie und Epigenetik (MPI-IE) / Max Planck Institute of Immunobiology and Epigenetics
Germany (DE)
Germany (DE)
Technische Universität Dresden
Germany (DE)
Max-Planck-Institut für Immunbiologie und Epigenetik (MPI-IE) / Max Planck Institute of Immunobiology and Epigenetics
Germany (DE)
How to cite
APA:
Kolter, J., Feuerstein, R., Zeis, P., Hagemeyer, N., Paterson, N., D'Errico, P.,... Henneke, P. (2019). A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity, 50(6), 1482-1497.e7. https://doi.org/10.1016/j.immuni.2019.05.009
MLA:
Kolter, Julia, et al. "A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves." Immunity 50.6 (2019): 1482-1497.e7.
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