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The aorta can act as a site of naïve CD4+ T-cell priming

Macritchie N, Grassia G, Noonan J, Cole JE, Hughes CE, Schroeder J, Benson RA, Cochain C, Zernecke A, Guzik TJ, Garside P, Monaco C, Maffia P (2020)

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Publication Type: Journal article

Publication year: 2020

Journal

Book Volume: 116

Pages Range: 306-316

Journal Issue: 2

DOI: 10.1093/cvr/cvz102

Abstract

Aims: Aortic adaptive immunity plays a role in atherosclerosis; however, the precise mechanisms leading to T-cell activation in the arterial wall remain poorly understood. Methods and results: Here, we have identified naïve T cells in the aorta of wild-Type and T-cell receptor transgenic mice and we demonstrate that naïve T cells can be primed directly in the vessel wall with both kinetics and frequency of T-cell activation found to be similar to splenic and lymphoid T cells. Aortic homing of naïve T cells is regulated at least in part by the P-selectin glycosylated ligand-1 receptor. In experimental atherosclerosis the aorta supports CD4+ T-cell activation selectively driving Th1 polarization. By contrast, secondary lymphoid organs display Treg expansion. Conclusion: Our results demonstrate that the aorta can support T-cell priming and that naïve T cells traffic between the circulation and vessel wall. These data underpin the paradigm that local priming of T cells specific for plaque antigens contributes to atherosclerosis progression.

Involved external institutions

How to cite

APA:

Macritchie, N., Grassia, G., Noonan, J., Cole, J.E., Hughes, C.E., Schroeder, J.,... Maffia, P. (2020). The aorta can act as a site of naïve CD4+ T-cell priming. Cardiovascular Research, 116(2), 306-316. https://doi.org/10.1093/cvr/cvz102

MLA:

Macritchie, Neil, et al. "The aorta can act as a site of naïve CD4+ T-cell priming." Cardiovascular Research 116.2 (2020): 306-316.

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