Truhn D, Brill N, Braun B, Merhof D, Kuhl C, Knobe M, Thuering J, Nebelung S (2020)
Publication Type: Journal article
Publication year: 2020
Book Volume: 101
Article Number: 103428
DOI: 10.1016/j.jmbbm.2019.103428
Response to loading of soft tissues as assessed by advanced magnetic resonance imaging (MRI) techniques is a promising approach to evaluate tissue functionality beyond (statically obtained) structural and compositional features. As cartilage and meniscus pathologies are closely intertwined in osteoarthritis (OA) and beyond, both tissues should ideally be studied to elucidate further the underlying mechanisms involved in load transmission and its failure leading to OA. Hence, we devised, constructed and validated a dedicated MRI-compatible pneumatic force-controlled loading device to study cartilage and meniscus functionality in a standardized and reproducible manner and in reference to alternative tissue evaluation methods. Mechanical reference measurements using digital force sensors confirmed the reproducible application of forces in the range of 0–76N. To demonstrate the device's utility in a basic research context, MRI measurements of human articular cartilage (obtained from the lateral femoral condyle, n = 5) and meniscus (obtained from lateral meniscus body, n = 5) were performed in the unloaded (δ
APA:
Truhn, D., Brill, N., Braun, B., Merhof, D., Kuhl, C., Knobe, M.,... Nebelung, S. (2020). A multi-purpose force-controlled loading device for cartilage and meniscus functionality assessment using advanced MRI techniques. Journal of the Mechanical Behavior of Biomedical Materials, 101. https://doi.org/10.1016/j.jmbbm.2019.103428
MLA:
Truhn, Daniel, et al. "A multi-purpose force-controlled loading device for cartilage and meniscus functionality assessment using advanced MRI techniques." Journal of the Mechanical Behavior of Biomedical Materials 101 (2020).
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