Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies?
Constantinescu C, Pasca S, Tat T, Teodorescu P, Vlad C, Iluta S, Dima D, Tomescu D, Scarlatescu E, Tanase A, Sigurjonsson OE, Colita A, Einsele H, Tomuleasa C (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 8
Journal Issue: 1
Abstract
Recently, an increasing number of novel drugs were approved in oncology and hematology. Nevertheless, pharmacology progress comes with a variety of side effects, of which cytokine release syndrome (CRS) is a potential complication of some immunotherapies that can lead to multiorgan failure if not diagnosed and treated accordingly. CRS generally occurs with therapies that lead to highly activated T cells, like chimeric antigen receptor T cells or in the case of bispecific T-cell engaging antibodies. This, in turn, leads to a proinflammatory state with subsequent organ damage. To better manage CRS there is a need for specific therapies or to repurpose strategies that are already known to be useful in similar situations. Current management strategies for CRS are represented by anticytokine directed therapies and corticosteroids. Based on its pathophysiology and the resemblance of CRS to sepsis and septic shock, as well as based on the principles of initiation of continuous renal replacement therapy (CRRT) in sepsis, we propose the rationale of using CRRT therapy as an adjunct treatment in CRS where all the other approaches have failed in controlling the clinically significant manifestations.
Involved external institutions
Iuliu Hațieganu University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie "Iuliu Hațieganu" (UMF Cluj)
Romania (RO)
Institute of Oncology Prof. Dr. Ion Chiricuta
Romania (RO)
Carol Davila University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie „Carol Davila” (UMF București)
Romania (RO)
Spitalul Clinic Fundeni Bucuresti
Romania (RO)
Reykjavik University
Iceland (IS)
Universitätsklinikum Würzburg
Germany (DE)
Romania (RO)
Institute of Oncology Prof. Dr. Ion Chiricuta
Romania (RO)
Carol Davila University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie „Carol Davila” (UMF București)
Romania (RO)
Spitalul Clinic Fundeni Bucuresti
Romania (RO)
Reykjavik University
Iceland (IS)
Universitätsklinikum Würzburg
Germany (DE)
How to cite
APA:
Constantinescu, C., Pasca, S., Tat, T., Teodorescu, P., Vlad, C., Iluta, S.,... Tomuleasa, C. (2020). Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies? Journal for ImmunoTherapy of Cancer, 8(1). https://doi.org/10.1136/jitc-2020-000742
MLA:
Constantinescu, Catalin, et al. "Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies?" Journal for ImmunoTherapy of Cancer 8.1 (2020).
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