Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies

Lejeune M, Kose MC, Duray E, Einsele H, Beguin Y, Caers J (2020)

Publication Type: Journal article, Review article

Publication year: 2020

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 11

Article Number: 762

DOI: 10.3389/fimmu.2020.00762

Abstract

Bispecific antibodies (BsAbs) are designed to recognize and bind to two different antigens or epitopes. In the last few decades, BsAbs have been developed within the context of cancer therapies and in particular for the treatment of hematologic B-cell malignancies. To date, more than one hundred different BsAb formats exist, including bispecific T-cell engagers (BiTEs), and new constructs are constantly emerging. Advances in protein engineering have enabled the creation of BsAbs with specific mechanisms of action and clinical applications. Moreover, a better understanding of resistance and evasion mechanisms, as well as advances in the protein engineering and in immunology, will help generating a greater variety of BsAbs to treat various cancer types. This review focuses on T-cell-engaging BsAbs and more precisely on the various BsAb formats currently being studied in the context of B-cell malignancies, on ongoing clinical trials and on the clinical concerns to be taken into account in the development of new BsAbs.

Involved external institutions

University of Liège (ULg) / Université de Liège BE Belgium (BE) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Lejeune, M., Kose, M.C., Duray, E., Einsele, H., Beguin, Y., & Caers, J. (2020). Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.00762

MLA:

Lejeune, Margaux, et al. "Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies." Frontiers in Immunology 11 (2020).

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