Multiple myeloma—dynamic developments regarding disease understanding and therapy Multiples Myelom – dynamische Entwicklungen in Krankheitsverständnis und Therapie
Steinbrunn T, Knop S, Einsele H (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 26
Pages Range: 661-672
Journal Issue: 7
DOI: 10.1007/s00761-020-00780-z
Abstract
Multiple myeloma is a clonal plasma cell malignancy which is primarily located in the bone marrow and leads to the suppression of the normal hematopoiesis. The entity has its highest incidence in the elderly. Advances in molecular genetic diagnostics have significantly broadened the understanding of the disease’s underlying biology. Stepwise introduction of novel drugs such as proteasome inhibitors, immunomodulatory drugs and monoclonal antibodies as well as the use of effective combination therapies have markedly improved the prognosis of patients including those with multiple prior lines of therapy. However, cure is still not possible. Novel therapeutic strategies primarily using immunological and targeted approaches will enrich future treatment options and further improve survival for those affected by multiple myeloma.
Involved external institutions
Germany (DE)How to cite
APA:
Steinbrunn, T., Knop, S., & Einsele, H. (2020). Multiple myeloma—dynamic developments regarding disease understanding and therapy Multiples Myelom – dynamische Entwicklungen in Krankheitsverständnis und Therapie. Onkologe, 26(7), 661-672. https://doi.org/10.1007/s00761-020-00780-z
MLA:
Steinbrunn, Torsten, Stefan Knop, and Hermann Einsele. "Multiple myeloma—dynamic developments regarding disease understanding and therapy Multiples Myelom – dynamische Entwicklungen in Krankheitsverständnis und Therapie." Onkologe 26.7 (2020): 661-672.
BibTeX: Download