18f-fdg, 11c-methionine, and 68ga-pentixafor pet/ct in patients with smoldering multiple myeloma: Imaging pattern and clinical features

Zhou X, Dierks A, Kertels O, Kircher M, Schirbel A, Samnick S, Buck AK, Knorz S, Bockle D, Scheller L, Messerschmidt J, Barakat M, Kortum KM, Rasche L, Einsele H, Lapa C (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Cancers MDPI

Book Volume: 12

Pages Range: 1-11

Article Number: 2333

Journal Issue: 8

DOI: 10.3390/cancers12082333

Abstract

This study aimed to explore the correlation between imaging patterns and clinical features in patients with smoldering multiple myeloma (SMM) who simultaneously underwent 18F-FDG, 11C-Methionine, and 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT). We retrieved and analyzed clinical characteristics and PET imaging data of 10 patients with SMM. We found a significant correlation between bone marrow (BM) plasma cell (PC) infiltration and mean standardized uptake values (SUVmean) of lumbar vertebrae L2-L4 on 11C-Methionine PET/CT scans (r = 0.676, p = 0.031) and 68Ga-Pentixafor PET/CT scans (r = 0.839, p = 0.002). However, there was no significant correlation between BM involvement and SUVmean of lumbar vertebrae L2-L4 on 18F-FDG PET/CT scans (r = 0.558, p = 0.093). Similarly, mean target-to-background ratios (TBRmean) of lumbar vertebrae L2-L4 also correlated with bone marrow plasma cell (BMPC) infiltration in 11C-Methionine PET/CT (r = 0.789, p = 0.007) and 68Ga-Pentixafor PET/CT (r = 0.724, p = 0.018) PET/CT. In contrast, we did not observe a significant correlation between BMPC infiltration rate and TBRmean in 18F-FDG PET/CT (r = 0.355, p = 0.313). Additionally, on 11C-Methionine PET/CT scans, we found a significant correlation between BMPC infiltration and TBRmax of lumbar vertebrae L2-L4 (r = 0.642, p = 0.045). In conclusion, 11C-Methionine and 68Ga-Pentixafor PET/CT demonstrate higher sensitivity than 18F-FDG PET/CT in detecting BM involvement in SMM.

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE)

How to cite

APA:

Zhou, X., Dierks, A., Kertels, O., Kircher, M., Schirbel, A., Samnick, S.,... Lapa, C. (2020). 18f-fdg, 11c-methionine, and 68ga-pentixafor pet/ct in patients with smoldering multiple myeloma: Imaging pattern and clinical features. Cancers, 12(8), 1-11. https://doi.org/10.3390/cancers12082333

MLA:

Zhou, Xiang, et al. "18f-fdg, 11c-methionine, and 68ga-pentixafor pet/ct in patients with smoldering multiple myeloma: Imaging pattern and clinical features." Cancers 12.8 (2020): 1-11.

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