Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids
Marsee A, Roos FJM, Verstegen MMA, Gehart H, De Koning E, Lemaigre F, Forbes SJ, Peng WC, Huch M, Takebe T, Vallier L, Clevers H, Van Der Laan LJW, Spee B (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Book Volume: 28
Pages Range: 816-832
Journal Issue: 5
DOI: 10.1016/j.stem.2021.04.005
Abstract
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.
Involved external institutions
Universiteit Utrecht (UU) / Utrecht University
Netherlands (NL)
Erasmus University Medical Center (MC)
Netherlands (NL)
Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich
Switzerland (CH)
Royal Netherlands Academy of Arts and Sciences / Koninklijke Nederlandse Akademie van Wetenschappen (KNAW)
Netherlands (NL)
Université Catholique de Louvain (UCL)
Belgium (BE)
University of Edinburgh
United Kingdom (GB)
Princess Máxima Center
Netherlands (NL)
Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Germany (DE)
Cincinnati Children's Hospital Medical Center
United States (USA) (US)
University of Cambridge
United Kingdom (GB)
Netherlands (NL)
Erasmus University Medical Center (MC)
Netherlands (NL)
Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich
Switzerland (CH)
Royal Netherlands Academy of Arts and Sciences / Koninklijke Nederlandse Akademie van Wetenschappen (KNAW)
Netherlands (NL)
Université Catholique de Louvain (UCL)
Belgium (BE)
University of Edinburgh
United Kingdom (GB)
Princess Máxima Center
Netherlands (NL)
Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Germany (DE)
Cincinnati Children's Hospital Medical Center
United States (USA) (US)
University of Cambridge
United Kingdom (GB)
How to cite
APA:
Marsee, A., Roos, F.J.M., Verstegen, M.M.A., Gehart, H., De Koning, E., Lemaigre, F.,... Spee, B. (2021). Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids. Cell Stem Cell, 28(5), 816-832. https://dx.doi.org/10.1016/j.stem.2021.04.005
MLA:
Marsee, Ary, et al. "Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids." Cell Stem Cell 28.5 (2021): 816-832.
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