T-Cell immune surveillance in allogenic stem cell transplant recipients: Are whole blood-based assays ready to challenge ELISPOT?

Lauruschkat CD, Page L, Etter S, Weis P, Gamon F, Kraus S, Einsele H, Wurster S, Loeffler J (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Open Forum Infectious Diseases Oxford University Press

Book Volume: 8

Article Number: ofaa547

Journal Issue: 1

DOI: 10.1093/ofid/ofaa547

Abstract

We compared the feasibility of 4 cytomegalovirus (CMV)- and Aspergillus-reactive T-cell immunoassay protocols in allogenic stem cell transplant recipients. While enzyme-linked immunospot performed best overall, logistically advantageous whole blood-based assays performed comparably in patients with less severe lymphocytopenia. CMV-induced interferon-gamma responses correlated strongly across all protocols and showed high concordance with serology.

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE) University of Texas MD Anderson Cancer Center US United States (USA) (US)

How to cite

APA:

Lauruschkat, C.D., Page, L., Etter, S., Weis, P., Gamon, F., Kraus, S.,... Loeffler, J. (2021). T-Cell immune surveillance in allogenic stem cell transplant recipients: Are whole blood-based assays ready to challenge ELISPOT? Open Forum Infectious Diseases, 8(1). https://doi.org/10.1093/ofid/ofaa547

MLA:

Lauruschkat, Chris D., et al. "T-Cell immune surveillance in allogenic stem cell transplant recipients: Are whole blood-based assays ready to challenge ELISPOT?" Open Forum Infectious Diseases 8.1 (2021).

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