Sugar addiction: An Achilles’ heel of auto-immune diseases?

Zaiss DMW, Coffer PJ (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Cell Metabolism Elsevier (Cell Press)

Book Volume: 34

Pages Range: 503-505

Journal Issue: 4

DOI: 10.1016/j.cmet.2022.03.007

Abstract

In this issue of Cell Metabolism, Hochrein et al. identify a metabolic checkpoint controlling the transcriptional programming of effector CD4+ T cells. The authors show that GLUT3-mediated glucose import and ACLY-dependent acetyl-CoA generation control histone acetylation and, hence, the epigenetic imprinting of effector gene expression in differentiated effector CD4+ T cells. These findings suggest a novel therapeutic target for inflammation-associated diseases.

Involved external institutions

University Medical Centre Utrecht (UMC Utrecht) NL Netherlands (NL) University of Edinburgh GB United Kingdom (GB)

How to cite

APA:

Zaiss, D.M.W., & Coffer, P.J. (2022). Sugar addiction: An Achilles’ heel of auto-immune diseases? Cell Metabolism, 34(4), 503-505. https://doi.org/10.1016/j.cmet.2022.03.007

MLA:

Zaiss, Dietmar M. W., and Paul J. Coffer. "Sugar addiction: An Achilles’ heel of auto-immune diseases?" Cell Metabolism 34.4 (2022): 503-505.

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