Ernst L, Bruch S, Kopaczka M, Merhof D, Bleich A, Tolba RH, Talbot SR (2022)
Publication Type: Journal article
Publication year: 2022
Book Volume: 12
Article Number: 10910
Journal Issue: 1
DOI: 10.1038/s41598-022-14852-0
Despite its long establishment and applicability in mice pain detection, the Mouse Grimace Scale still seems to be underused in acute pain detection during chronic experiments. However, broadening its applicability can identify possible refinement approaches such as cumulative severity and habituation to painful stimuli. Therefore, this study focuses on two main aspects: First, five composite MGS criteria were evaluated with two independent methods (the MoBPs algorithm and a penalized least squares regression) and ranked for their relative importance. The most important variable was used in a second analysis to specifically evaluate the context of pain after an i.p. injection (intervention) in two treatment groups (CCl
APA:
Ernst, L., Bruch, S., Kopaczka, M., Merhof, D., Bleich, A., Tolba, R.H., & Talbot, S.R. (2022). A model-specific simplification of the Mouse Grimace Scale based on the pain response of intraperitoneal CCl4 injections. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-14852-0
MLA:
Ernst, Lisa, et al. "A model-specific simplification of the Mouse Grimace Scale based on the pain response of intraperitoneal CCl4 injections." Scientific Reports 12.1 (2022).
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