Heidemeier A, Thurner A, Metz C, Pabst T, Heidemeier H, Rasche L, Kortum KM, Einsele H, Grimm R, Weiland E, Bley TA (2022)
Publication Type: Journal article
Publication year: 2022
Book Volume: 29
Pages Range: e1-e8
Journal Issue: 1
DOI: 10.1016/j.acra.2020.09.016
Rationale and Objectives: Our study compared sensitivity, specificity, and accuracy of whole-body diffusion-weighted imaging (WB-DWI) using a b-value of 2000 s/mm2 with that of the commonly used b-value of 800 s/mm2 for depiction of active tumor sites in patients with plasma cell diseases. We introduced an ultrahigh b-value to reduce interfering signals from benign and post-therapeutic inactive lesions by suppressing T2-shine-through effects. Materials and Methods: The prospective single-center study included patients when they went through a whole-body MRI (WB-MRI) staging or response evaluation procedure. The apparent diffusion coefficient (ADC) and morphologic appearance served as reference for classifying focal lesions on WB-DWI as vital or post-therapeutic. Additionally, we compared our classification with patients’ serological markers of disease activity. Results: One hundred participants (65 ± 10 years, 58 men) underwent WB-DWI between June and October 2019. The detection rate of vital focal lesions was similar for both b-values with a sensitivity of 0.99 using b = 800 s/mm2 and 0.98 using b = 2000 s/mm2. By contrast, specificity and accuracy were 0.09 and 0.71 when using a b-value of 800 s/mm2, and 0.96 and 0.98 when using a b-value of 2000 s/mm2, respectively. The difference in specificity and accuracy was statistically significant (p < 0.001). Conclusion: Using a b-value of 2000 s/mm2 significantly improved the specificity of lesion detection with WB-DWI as compared to the commonly used b-value of 800 s/mm2. The high b-value significantly reduced signal intensities of post-therapeutic or benign lesions and provided a significantly more accurate representation of active tumor load.
APA:
Heidemeier, A., Thurner, A., Metz, C., Pabst, T., Heidemeier, H., Rasche, L.,... Bley, T.A. (2022). Whole-Body MRI with an Ultrahigh b-Value of 2000 s/mm2 Improves the Specificity of Diffusion-Weighted Imaging in Patients with Plasma Cell Dyscrasias. Academic Radiology, 29(1), e1-e8. https://doi.org/10.1016/j.acra.2020.09.016
MLA:
Heidemeier, Anke, et al. "Whole-Body MRI with an Ultrahigh b-Value of 2000 s/mm2 Improves the Specificity of Diffusion-Weighted Imaging in Patients with Plasma Cell Dyscrasias." Academic Radiology 29.1 (2022): e1-e8.
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