Epigenetic mechanisms regulating T-cell responses

Schmidl C, Delacher M, Huehn J, Feuerer M (2018)

Publication Type: Journal article, Review article

Publication year: 2018

Journal

Journal of Allergy and Clinical Immunology Elsevier

Book Volume: 142

Pages Range: 728-743

Journal Issue: 3

DOI: 10.1016/j.jaci.2018.07.014

Abstract

During the last decade, advances in sequencing technologies allowed production of a wealth of information on epigenetic modifications in T cells. Epigenome maps, in combination with mechanistic studies, have demonstrated that T cells undergo extensive epigenome remodeling in response to signals, which has a strong effect on phenotypic stability and function of lymphocytes. In this review we focus on DNA methylation, histone modifications, and chromatin structure as important epigenetic mechanisms involved in controlling T-cell responses. In particular, we discuss epigenetic processes in light of the development, activation, and differentiation of CD4+ T helper (TH), regulatory T, and CD8+ T cells. As central aspects of the adaptive immune system, we review mechanisms that ensure molecular memory, stability, plasticity, and exhaustion of T cells. We further discuss the effect of the tissue environment on imprinting T-cell epigenomes with potential implications for immunotherapy.

Involved external institutions

RCI - Regensburger Centrum für Interventionelle Immunologie DE Germany (DE) Helmholtz-Zentrum für Infektionsforschung (HZI) DE Germany (DE)

How to cite

APA:

Schmidl, C., Delacher, M., Huehn, J., & Feuerer, M. (2018). Epigenetic mechanisms regulating T-cell responses. Journal of Allergy and Clinical Immunology, 142(3), 728-743. https://doi.org/10.1016/j.jaci.2018.07.014

MLA:

Schmidl, Christian, et al. "Epigenetic mechanisms regulating T-cell responses." Journal of Allergy and Clinical Immunology 142.3 (2018): 728-743.

BibTeX: Download