Self-folding hydrogel bilayer for enhanced drug loading, encapsulation, and transport

Huang HW, Petruska AJ, Sakar MS, Skoura M, Ullrich F, Zhangm Q, Pane S, Nelson BJ (2016)

Publication Type: Conference contribution

Publication year: 2016

Journal

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society

Publisher: Institute of Electrical and Electronics Engineers Inc.

Book Volume: 2016-October

Pages Range: 2103-2106

Conference Proceedings Title: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Event location: Orlando, FL, USA

ISBN: 9781457702204

DOI: 10.1109/EMBC.2016.7591143

Abstract

Hydrogel-based robotic microdevices are currently investigated for minimally invasive medical procedures. Hydrogels are especially suited to targeted drug delivery applications as they are able to carry several times more drug solution than its dry weight. A major drawback of these system is that drug release takes place before reaching the targeted area in the body. We introduce a strategy based on a self-folding bilayer to prevent release during transportation without hindering the drug loading efficiency of the hydrogel. The drug is loaded into the hydrogel matrix at room temperature. When the temperature is increased to body temperature, the hydrogel-matrix collapses and the self-folded bilayer refolds into another tube. In this configuration, we observed a significant reduction in drug leakage with less than 5% drug loss during encapsulation. Finally, we demonstrate that the tube can be manipulated magnetically, which shows its potential use in targeted drug delivery applications.

Involved external institutions

Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich CH Switzerland (CH) École Polytechnique Fédérale de Lausanne (EPFL) CH Switzerland (CH)

How to cite

APA:

Huang, H.W., Petruska, A.J., Sakar, M.S., Skoura, M., Ullrich, F., Zhangm, Q.,... Nelson, B.J. (2016). Self-folding hydrogel bilayer for enhanced drug loading, encapsulation, and transport. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 2103-2106). Orlando, FL, USA: Institute of Electrical and Electronics Engineers Inc..

MLA:

Huang, Hen Wei, et al. "Self-folding hydrogel bilayer for enhanced drug loading, encapsulation, and transport." Proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, FL, USA Institute of Electrical and Electronics Engineers Inc., 2016. 2103-2106.

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