Bio-based Biodegradable and Biocompatible Hyperbranched Polyurethane: A Scaffold for Tissue Engineering

Das B, Chattopadhyay P, Mandal M, Voit B, Karak N (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Macromolecular Bioscience Wiley-VCH Verlag

Book Volume: 13

Pages Range: 126-139

Journal Issue: 1

DOI: 10.1002/mabi.201200244

Abstract

Hyperbranched polyurethanes are synthesized using TDI, PCL diol, butanediol, and pentaerythritol (1-5wt%) as the B4 reactant with and without the monoglyceride of sunflower oil. The biodegradation, physico-mechanical, and thermal properties are found to be tailored by varying the percentage weight of the branching unit. An MTT/hemolytic assay and subcutaneous implantation in Wistar rats followed by cytokine/ALP assay and histopathology studies confirm a better biocompatibility of HBPU with MG than without MG. HBPU supports the proliferation of dermatocytes with no toxic effect in major organs, in addition the in vitro degraded products are non-toxic. Cell adherence and proliferation endorse the bio-based HBPU as a prospective scaffold material in the niche of tissue engineering. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Involved external institutions

Tezpur University

India (IN) Defence Research Laboratory

India (IN) Leibniz-Institut für Polymerforschung Dresden e. V.

Germany (DE)

How to cite

APA:

Das, B., Chattopadhyay, P., Mandal, M., Voit, B., & Karak, N. (2013). Bio-based Biodegradable and Biocompatible Hyperbranched Polyurethane: A Scaffold for Tissue Engineering. Macromolecular Bioscience, 13(1), 126-139. https://dx.doi.org/10.1002/mabi.201200244

MLA:

Das, Beauty, et al. "Bio-based Biodegradable and Biocompatible Hyperbranched Polyurethane: A Scaffold for Tissue Engineering." Macromolecular Bioscience 13.1 (2013): 126-139.

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