Magnetic mesoporous bioactive glass scaffolds: Preparation, physicochemistry and biological properties

Zhu Y, Shang F, Li B, Dong Y, Liu Y, Lohe MR, Hanagata N, Kaskel S (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Journal of Materials Chemistry B Royal Society of Chemistry

Book Volume: 1

Pages Range: 1279-1288

Journal Issue: 9

DOI: 10.1039/c2tb00262k

Abstract

The magnetic 10Fe5Ca MBG scaffolds (Fe3O4-CaO- SiO2-P2O5 system) have been prepared by a combination of polyurethane sponge and P123 as co-templates and an evaporation-induced self-assembly (EISA) process through the substitution of Fe3O4 for CaO in the 15Ca MBG scaffolds (CaO-SiO 2-P2O5 system). The structure, magnetic heating, drug release, physicochemical and biological properties were systematically investigated. The results showed that the 10Fe5Ca MBG scaffolds had the interconnected macroporous structure with pore sizes ranging from 200 to 400 μm and the mesoporous wall with a peak pore size of ca. 3.34 nm. Also, the 10Fe5Ca MBG scaffolds exhibited similar mechanical strength, apatite-forming ability and sustained drug release behavior compared to the 15Ca MBG scaffolds. Importantly, the substitution of Fe3O4 for CaO in the MBG scaffolds induced a slower ion dissolution rate and more significant potential to stabilize the pH environment, and facilitated osteoblast cell proliferation, alkaline phosphatase (ALP) activity and osteogenic expression. In particular, the 10Fe5Ca MBG scaffolds could generate heat in an alternating magnetic field. Therefore, the magnetic 10Fe5Ca MBG scaffolds have potential for the regeneration of the critical-size bone defects caused by bone tumors by a combination of magnetic hyperthermia and local drug delivery therapy. © 2013 The Royal Society of Chemistry.

Involved external institutions

Nanjing University CN China (CN) University of Shanghai for Science and Technology (USST) CN China (CN) Technische Universität Dresden DE Germany (DE) National Institute of Materials Science (NIMS) JP Japan (JP)

How to cite

APA:

Zhu, Y., Shang, F., Li, B., Dong, Y., Liu, Y., Lohe, M.R.,... Kaskel, S. (2013). Magnetic mesoporous bioactive glass scaffolds: Preparation, physicochemistry and biological properties. Journal of Materials Chemistry B, 1(9), 1279-1288. https://doi.org/10.1039/c2tb00262k

MLA:

Zhu, Yufang, et al. "Magnetic mesoporous bioactive glass scaffolds: Preparation, physicochemistry and biological properties." Journal of Materials Chemistry B 1.9 (2013): 1279-1288.

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