Striegler C, Schumacher M, Effenberg C, Mueller M, Seckinger A, Schnettler R, Voit B, Hose D, Gelinsky M, Appelhans D (2015)
Publication Type: Journal article
Publication year: 2015
Book Volume: 15
Pages Range: 1283-1295
Journal Issue: 9
Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendritic glycopolymer and cellulose sulfate, for the proteasome inhibitor bortezomib. Both DDS are able to induce short-term retarded release of bortezomib from calcium phosphate bone cement in comparison to a burst-release of the drug from bone cement alone. Different release parameters have been evaluated to get a first insight into the release mechanism from bone cements. In addition, biocompatibility of the calcium phosphate cement, modified with the new DDS was investigated using human mesenchymal stromal cells.
APA:
Striegler, C., Schumacher, M., Effenberg, C., Mueller, M., Seckinger, A., Schnettler, R.,... Appelhans, D. (2015). Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions. Macromolecular Bioscience, 15(9), 1283-1295. https://doi.org/10.1002/mabi.201500085
MLA:
Striegler, Christin, et al. "Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions." Macromolecular Bioscience 15.9 (2015): 1283-1295.
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