Stiffness-dependent in vitro uptake and lysosomal acidification of colloidal particles
Hartmann R, Weidenbach M, Neubauer M, Fery A, Parak WJ (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 54
Pages Range: 1365-1368
Journal Issue: 4
Abstract
The physico-chemical properties of colloidal particles determine their uptake into cells. For a series of microparticles only one parameter, the mechanical stiffness, was varied, whereas other parameters such as size, shape, and charge were kept constant. The uptake was monitored in situ by analyzing individual particle trajectories including the progress of endocytosis, derived from local pH measurements around each particle. Evidence is presented that soft particles with low stiffness are transported faster to lysosomes than stiffer ones.
Involved external institutions
Germany (DE)How to cite
APA:
Hartmann, R., Weidenbach, M., Neubauer, M., Fery, A., & Parak, W.J. (2015). Stiffness-dependent in vitro uptake and lysosomal acidification of colloidal particles. Angewandte Chemie International Edition, 54(4), 1365-1368. https://doi.org/10.1002/anie.201409693
MLA:
Hartmann, Raimo, et al. "Stiffness-dependent in vitro uptake and lysosomal acidification of colloidal particles." Angewandte Chemie International Edition 54.4 (2015): 1365-1368.
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