Analysis of sequence-defined oligomers through Advanced Polymer Chromatography™ - mass spectrometry hyphenation

Berg MT, Mertens C, Du Prez F, Kühne TD, Herberg A, Kuckling D (2020)

Publication Type: Journal article

Publication year: 2020

Journal

RSC Advances Royal Society of Chemistry

Book Volume: 10

Pages Range: 35245-35252

Journal Issue: 58

DOI: 10.1039/d0ra06419j

Abstract

In recent years, sequence-defined oligomers have attracted increasing interest in the polymer community and the number of new applications such as macromolecular data storage and encryption is increasing. However, techniques allowing sequence differentiation are still lacking. In this study, the focus is put towards a new strategy allowing structural distinction between sequence-defined oligomers with identical molecular weight and composition, but bearing different sequences. This technique relies on the hyphenation of size exclusion chromatography and mass spectrometry, coupled with ion mobility separation. This approach allows for a quick and easy separation and identification of oligomers with different length and/or sequence.

Involved external institutions

Universität Paderborn DE Germany (DE) Universiteit Gent (UGent) / Ghent University BE Belgium (BE)

How to cite

APA:

Berg, M.-T., Mertens, C., Du Prez, F., Kühne, T.D., Herberg, A., & Kuckling, D. (2020). Analysis of sequence-defined oligomers through Advanced Polymer Chromatography™ - mass spectrometry hyphenation. RSC Advances, 10(58), 35245-35252. https://doi.org/10.1039/d0ra06419j

MLA:

Berg, Marie-Theres, et al. "Analysis of sequence-defined oligomers through Advanced Polymer Chromatography™ - mass spectrometry hyphenation." RSC Advances 10.58 (2020): 35245-35252.

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