Redox- and pH-Responsive Polymersomes with Ferrocene Moieties Exhibiting Peroxidase-like, Chemoenzymatic Activity and H2O2-Responsive Release Behavior

Moreno S, Huebner H, Effenberg C, Boye S, Ramuglia A, Schmitt D, Voit B, Weidinger IM, Gallei M, Appelhans D (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Biomacromolecules American Chemical Society

Book Volume: 23

Pages Range: 4655-4667

Journal Issue: 11

DOI: 10.1021/acs.biomac.2c00901

Abstract

The development of compartments for the design of cascade reactions in a local space requires a selective spatiotemporal control. The combination of enzyme-loaded polymersomes with enzymelike units shows a great potential in further refining the diffusion barrier and the type of reactions in nanoreactors. Herein, pH-responsive and ferrocene-containing block copolymers were synthesized to realize pH-stable and multiresponsive polymersomes. Permeable membrane, peroxidase-like behavior induced by the redox-responsive ferrocene moieties and release properties were validated using cyclovoltammetry, dye TMB assay, and rupture of host-guest interactions with β-cyclodextrin, respectively. Due to the incorporation of different block copolymers, the membrane permeability of glucose oxidase-loaded polymersomes was changed by increasing extracellular glucose concentration and in TMB assay, allowing for the chemoenzymatic cascade reaction. This study presents a potent synthetic, multiresponsive nanoreactor platform with tunable (e.g., redox-responsive) membrane properties for potential application in therapeutics.

Involved external institutions

Technische Universität Dresden DE Germany (DE) Leibniz-Institut für Polymerforschung Dresden e. V. DE Germany (DE) Universität des Saarlandes (UdS) DE Germany (DE)

How to cite

APA:

Moreno, S., Huebner, H., Effenberg, C., Boye, S., Ramuglia, A., Schmitt, D.,... Appelhans, D. (2022). Redox- and pH-Responsive Polymersomes with Ferrocene Moieties Exhibiting Peroxidase-like, Chemoenzymatic Activity and H2O2-Responsive Release Behavior. Biomacromolecules, 23(11), 4655-4667. https://doi.org/10.1021/acs.biomac.2c00901

MLA:

Moreno, Silvia, et al. "Redox- and pH-Responsive Polymersomes with Ferrocene Moieties Exhibiting Peroxidase-like, Chemoenzymatic Activity and H2O2-Responsive Release Behavior." Biomacromolecules 23.11 (2022): 4655-4667.

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