Hollow Spherical Covalent Organic Frameworks from Nonplanar or Planar Monomers for the Fluorescence Detection of Telomere DNA: Role of the 2-(2-Azidoethoxy)ethoxy Group

Ahmed LR, Gilmanova L, Pan CT, Kaskel S, El-Mahdy AFM (2022)

Publication Type: Journal article

Publication year: 2022

Journal

ACS Applied Polymer Materials ACS Publications

Book Volume: 4

Pages Range: 9132-9143

Journal Issue: 12

DOI: 10.1021/acsapm.2c01460

Abstract

Construction of covalent organic frameworks (COFs) with a hollow and uniform morphology─regardless of whether planar or nonplanar building blocks are employed─is still challenging. Herein, we report a facile strategy for the self-assembly and template-free synthesis of hollow spherical COFs by increasing the percentage content of 2-(2-azidoethoxy)ethoxy groups in the pore skeleton of a COF. Moreover, the morphological diversity dependent on the percentage content of 2-(2-azidoethoxy)ethoxy groups in the COF structure is observed. COF-100%N3, which is formed by the polycondensation of the nonplanar 1,3,5-tris(4-aminophenyl)benzene monomer, having the highest percentage content of the 2-(2-azidoethoxy)ethoxy group (100%), is self-assembled into homogeneous hollow spheres. For the first time, our strategy effectively explores the self-assembly of the planar monomer into a hollow spherical COF. Hollow spherical TPP-COF-100%N3is formed via the polycondensation of the planar 2,4,6-tris(4-aminophenyl)pyridine monomer and 2-(2-azidoethoxy)ethoxy group (100%). Due to the favorable characteristics of its specific surface area and hollow mesoporous nature, spherical COF-100%N3functions as an enticing sensing platform for the fluorescence-selective and -sensitive detection of telomere DNA. Consequently, this research study documents a facile strategy for constructing a unique hollow spherical COF and expands the application of COFs as fluorescent platforms for DNA detection.

Involved external institutions

National Sun Yat-sen University TW Taiwan (TW) Technische Universität Dresden DE Germany (DE)

How to cite

APA:

Ahmed, L.R., Gilmanova, L., Pan, C.-T., Kaskel, S., & El-Mahdy, A.F.M. (2022). Hollow Spherical Covalent Organic Frameworks from Nonplanar or Planar Monomers for the Fluorescence Detection of Telomere DNA: Role of the 2-(2-Azidoethoxy)ethoxy Group. ACS Applied Polymer Materials, 4(12), 9132-9143. https://doi.org/10.1021/acsapm.2c01460

MLA:

Ahmed, Lamiaa Reda, et al. "Hollow Spherical Covalent Organic Frameworks from Nonplanar or Planar Monomers for the Fluorescence Detection of Telomere DNA: Role of the 2-(2-Azidoethoxy)ethoxy Group." ACS Applied Polymer Materials 4.12 (2022): 9132-9143.

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