Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma
Ried JS, Baurecht H, Stueckler F, Krumsiek J, Gieger C, Heinrich J, Kabesch M, Prehn C, Peters A, Rodriguez E, Schulz H, Strauch K, Suhre K, Wang-Sattler R, Wichmann HE, Theis FJ, Illig T, Adamski J, Weidinger S (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Book Volume: 68
Pages Range: 629-636
Journal Issue: 5
DOI: 10.1111/all.12110
Abstract
Background Genome-wide association studies (GWAS) have identified many risk loci for asthma, but effect sizes are small, and in most cases, the biological mechanisms are unclear. Targeted metabolite quantification that provides information about a whole range of pathways of intermediary metabolism can help to identify biomarkers and investigate disease mechanisms. Combining genetic and metabolic information can aid in characterizing genetic association signals with high resolution. This work aimed to investigate the interrelation of current asthma, candidate asthma risk alleles and a panel of metabolites. Methods We investigated 151 metabolites, quantified by targeted mass spectrometry, in fasting serum of asthmatic and nonasthmatic individuals from the population-based KORA F4 study (N = 2925). In addition, we analysed effects of single-nucleotide polymorphisms (SNPs) at 24 asthma risk loci on these metabolites. Results Increased levels of various phosphatidylcholines and decreased levels of various lyso-phosphatidylcholines were associated with asthma. Likewise, asthma risk alleles from the PDED3 and MED24 genes at the asthma susceptibility locus 17q21 were associated with increased concentrations of various phosphatidylcholines with consistent effect directions. Conclusions Our study demonstrated the potential of metabolomics to infer asthma-related biomarkers by the identification of potentially deregulated phospholipids that associate with asthma and asthma risk alleles. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
Involved external institutions
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Universitätsklinikum Schleswig-Holstein (UKSH)
Germany (DE)
Krankenhaus Barmherzige Brüder
Germany (DE)
Germany (DE)
Universitätsklinikum Schleswig-Holstein (UKSH)
Germany (DE)
Krankenhaus Barmherzige Brüder
Germany (DE)
How to cite
APA:
Ried, J.S., Baurecht, H., Stueckler, F., Krumsiek, J., Gieger, C., Heinrich, J.,... Weidinger, S. (2013). Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma. Allergy, 68(5), 629-636. https://doi.org/10.1111/all.12110
MLA:
Ried, J. S., et al. "Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma." Allergy 68.5 (2013): 629-636.
BibTeX: Download