Enescu M, Bhushan M, Hill EJ, Franklin J, Anderson EM, Sharma RA, Schnabel JA (2013)
Publication Type: Conference contribution
Publication year: 2013
Book Volume: 8669
Conference Proceedings Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Event location: USA
ISBN: 9780819494436
DOI: 10.1117/12.2007036
Dynamic contrast-enhanced MRI is a dynamic imaging technique that is now widely used for cancer imaging. Changes in tumour microvasculature are typically quantified by pharmacokinetic modelling of the contrast uptake curves. Reliable pharmacokinetic parameter estimation depends on the measurement of the arterial in- put function, which can be obtained from arterial blood sampling, or extracted from the image data directly. However, arterial blood sampling poses additional risks to the patient, and extracting the input function from MR intensities is not reliable. In this work, we propose to compute a perfusion CT based arterial input function, which is then employed for dynamic contrast enhanced MRI pharmacokinetic parameter estimation. Here, pa- rameter estimation is performed simultaneously with intra-sequence motion correction by using nonlinear image registration. K
APA:
Enescu, M., Bhushan, M., Hill, E.J., Franklin, J., Anderson, E.M., Sharma, R.A., & Schnabel, J.A. (2013). pCT derived arterial input function for improved pharmacokinetic analysis of longitudinal dceMRI for colorectal cancer. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. USA.
MLA:
Enescu, Monica, et al. "pCT derived arterial input function for improved pharmacokinetic analysis of longitudinal dceMRI for colorectal cancer." Proceedings of the Medical Imaging 2013: Image Processing, USA 2013.
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