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pCT derived arterial input function for improved pharmacokinetic analysis of longitudinal dceMRI for colorectal cancer

Enescu M, Bhushan M, Hill EJ, Franklin J, Anderson EM, Sharma RA, Schnabel JA (2013)

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Publication Type: Conference contribution

Publication year: 2013

Journal

Book Volume: 8669

Conference Proceedings Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Event location: USA

ISBN: 9780819494436

DOI: 10.1117/12.2007036

Abstract

Dynamic contrast-enhanced MRI is a dynamic imaging technique that is now widely used for cancer imaging. Changes in tumour microvasculature are typically quantified by pharmacokinetic modelling of the contrast uptake curves. Reliable pharmacokinetic parameter estimation depends on the measurement of the arterial in- put function, which can be obtained from arterial blood sampling, or extracted from the image data directly. However, arterial blood sampling poses additional risks to the patient, and extracting the input function from MR intensities is not reliable. In this work, we propose to compute a perfusion CT based arterial input function, which is then employed for dynamic contrast enhanced MRI pharmacokinetic parameter estimation. Here, pa- rameter estimation is performed simultaneously with intra-sequence motion correction by using nonlinear image registration. Ktrans maps obtained with this approach were compared with those obtained using a population averaged arterial input function, i.e. Orton. The dataset comprised 5 rectal cancer patients, who had been imaged with both perfusion CT and dynamic contrast enhanced MRI, before and after the administration of a radiosensitising drug. Ktrans distributions pre and post therapy were computed using both the perfusion CT and the Orton arterial input function. Perfusion CT derived arterial input functions can be used for pharmacokinetic modelling of dynamic contrast enhanced MRI data, when perfusion CT images of the same patients are available. Compared to the Orton model, perfusion CT functions have the potential to give a more accurate separation between responders and non-responders. © 2013 SPIE.

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How to cite

APA:

Enescu, M., Bhushan, M., Hill, E.J., Franklin, J., Anderson, E.M., Sharma, R.A., & Schnabel, J.A. (2013). pCT derived arterial input function for improved pharmacokinetic analysis of longitudinal dceMRI for colorectal cancer. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. USA.

MLA:

Enescu, Monica, et al. "pCT derived arterial input function for improved pharmacokinetic analysis of longitudinal dceMRI for colorectal cancer." Proceedings of the Medical Imaging 2013: Image Processing, USA 2013.

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