A Bayesian approach for spatially adaptive regularisation in non-rigid registration
Simpson IJ, Woolrich MW, Cardoso MJ, Cash DM, Modat M, Schnabel JA, Ourselin S (2013)
Publication Type: Conference contribution
Publication year: 2013
Journal
Book Volume: 8150 LNCS
Pages Range: 10-18
Conference Proceedings Title: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Event location: JPN
ISBN: 9783642407628
DOI: 10.1007/978-3-642-40763-5_2
Abstract
This paper introduces a novel method for inferring spatially varying regularisation in non-rigid registration. This is achieved through full Bayesian inference on a probabilistic registration model, where the prior on transformations is parametrised as a weighted mixture of spatially localised components. Such an approach has the advantage of allowing the registration to be more flexibly driven by the data than a more traditional global regularisation scheme, such as bending energy. The proposed method adaptively determines the influence of the prior in a local region. The importance of the prior may be reduced in areas where the data better supports deformations, or can enforce a stronger constraint in less informative areas. Consequently, the use of such a spatially adaptive prior may reduce the unwanted impact of regularisation on the inferred deformation field. This is especially important for applications such as tensor based morphometry, where the features of interest are directly derived from the deformation field. The proposed approach is demonstrated with application to tensor based morphometry analysis of subjects with Alzheimer's disease and healthy controls. The results show that using the proposed spatially adaptive prior leads to deformation fields that have a substantially lower average complexity, but which also provide more accurate localisation of statistical group differences. © 2013 Springer-Verlag.
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United Kingdom (GB)How to cite
APA:
Simpson, I.J., Woolrich, M.W., Cardoso, M.J., Cash, D.M., Modat, M., Schnabel, J.A., & Ourselin, S. (2013). A Bayesian approach for spatially adaptive regularisation in non-rigid registration. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (pp. 10-18). JPN.
MLA:
Simpson, Ivor J.A., et al. "A Bayesian approach for spatially adaptive regularisation in non-rigid registration." Proceedings of the 16th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2013, JPN 2013. 10-18.
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