Imaging of Metastatic Lymph Nodes by X-ray Phase-Contrast Micro-Tomography
Jensen TH, Bech M, Binderup T, Boettiger A, David C, Weitkamp T, Zanette I, Reznikova E, Mohr J, Rank F, Feidenhans'L R, Kjaer A, Hojgaard L, Pfeiffer F (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Book Volume: 8
Article Number: e54047
Journal Issue: 1
DOI: 10.1371/journal.pone.0054047
Abstract
Invasive cancer causes a change in density in the affected tissue, which can be visualized by x-ray phase-contrast tomography. However, the diagnostic value of this method has so far not been investigated in detail. Therefore, the purpose of this study was, in a blinded manner, to investigate whether malignancy could be revealed by non-invasive x-ray phase-contrast tomography in lymph nodes from breast cancer patients. Seventeen formalin-fixed paraffin-embedded lymph nodes from 10 female patients (age range 37-83 years) diagnosed with invasive ductal carcinomas were analyzed by X-ray phase-contrast tomography. Ten lymph nodes had metastatic deposits and 7 were benign. The phase-contrast images were analyzed according to standards for conventional CT images looking for characteristics usually only visible by pathological examinations. Histopathology was used as reference. The result of this study was that the diagnostic sensitivity of the image analysis for detecting malignancy was 100% and the specificity was 87%. The positive predictive value was 91% for detecting malignancy and the negative predictive value was 100%. We conclude that x-ray phase-contrast imaging can accurately detect density variations to obtain information regarding lymph node involvement previously inaccessible with standard absorption x-ray imaging. © 2013 Jensen et al.
Involved external institutions
University of Copenhagen
Denmark (DK)
Technische Universität München (TUM)
Germany (DE)
Rigshospitalet
Denmark (DK)
Paul Scherrer Institute (PSI)
Switzerland (CH)
Synchrotron SOLEIL
France (FR)
Karlsruhe Institute of Technology (KIT)
Germany (DE)
Denmark (DK)
Technische Universität München (TUM)
Germany (DE)
Rigshospitalet
Denmark (DK)
Paul Scherrer Institute (PSI)
Switzerland (CH)
Synchrotron SOLEIL
France (FR)
Karlsruhe Institute of Technology (KIT)
Germany (DE)
How to cite
APA:
Jensen, T.H., Bech, M., Binderup, T., Boettiger, A., David, C., Weitkamp, T.,... Pfeiffer, F. (2013). Imaging of Metastatic Lymph Nodes by X-ray Phase-Contrast Micro-Tomography. PLoS ONE, 8(1). https://doi.org/10.1371/journal.pone.0054047
MLA:
Jensen, Torben Haugaard, et al. "Imaging of Metastatic Lymph Nodes by X-ray Phase-Contrast Micro-Tomography." PLoS ONE 8.1 (2013).
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