Optical attenuation correction in multispectral optoacoustic tomography with logarithm unmixing
Dean-Ben XL, Buehler A, Ntziachristos V, Razansky D (2013)
Publication Type: Conference contribution
Publication year: 2013
Publisher: Optical Society of America (OSA)
Conference Proceedings Title: Optics InfoBase Conference Papers
Event location: DEU
ISBN: 9780819496461
DOI: 10.1117/12.2033351
Abstract
Quantification of extrinsically administered contrast agents in optoacoustic (photoacoustic) tomography is a challenging task, mainly due to spectrally-dependent contributions from absorbing background tissue chromophores leading to strong changes in the light fluence for different positions and wavelengths. Herein we present a procedure capable of self-calibrating light fluence variations for quantitative imaging of the distribution of photo-absorbing agents. The method makes use of a logarithmic representation of the images taken at different wavelengths assisted with a blind unmixing approach. It is shown that the serial expansion of the logarithm of an image contains a term representing the ratio between absorption of the probe of interest and other background components. Provided the background variations are not very high, this term can be isolated with an unmixing algorithm, so that the concentration of the probe can subsequently be resolved. © 2013 OSA-SPIE.
Involved external institutions
Germany (DE)How to cite
APA:
Dean-Ben, X.L., Buehler, A., Ntziachristos, V., & Razansky, D. (2013). Optical attenuation correction in multispectral optoacoustic tomography with logarithm unmixing. In Optics InfoBase Conference Papers. DEU: Optical Society of America (OSA).
MLA:
Dean-Ben, X. Luis, et al. "Optical attenuation correction in multispectral optoacoustic tomography with logarithm unmixing." Proceedings of the European Conference on Biomedical Optics, ECBO 2013, DEU Optical Society of America (OSA), 2013.
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