Multispectral optoacoustic tomography of myocardial infarction
Taruttis A, Wildgruber M, Kosanke K, Beziere N, Licha K, Haag R, Aichler M, Walch A, Rummeny E, Ntziachristos V (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Book Volume: 1
Pages Range: 3-8
Journal Issue: 1
DOI: 10.1016/j.pacs.2012.11.001
Abstract
Objectives: To investigate the feasibility of a high resolution optical imaging strategy for myocardial infarction. Background: Near-infrared approaches to imaging cardiovascular disease enable visualization of disease-associated biological processes in vivo. However, even at the scale of small animals, the strong scattering of light prevents high resolution imaging after the first 1-2. mm of tissue, leading to degraded signal localization. Methods: Multispectral optoacoustic tomography (MSOT) was used to non-invasively image myocardial infarction (MI) in a murine model of coronary artery ligation at resolutions not possible with current deep-tissue optical imaging methods. Post-MI imaging was based on resolving the spectral absorption signature of a dendritic polyglycerol sulfate-based (dPGS) near-infrared imaging agent targeted to P- and L-selectin. Results: In vivo imaging succeeded in detection of the agent in the injured myocardium after intravenous injection. The high anatomic resolution (<200. μm) achieved by the described method allowed signals originating in the infarcted heart to be distinguished from uptake in adjacent regions. Histological analysis found dPGS signal in infarcted areas, originating from leukocytes and endothelial cells. Conclusions: MSOT imaging of myocardial infarction provides non-invasive visualization of optical contrast with a high spatial resolution that is not degraded by the scattering of light. © 2012 Elsevier GmbH.
Involved external institutions
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Klinikum rechts der Isar
Germany (DE)
mivenion GmbH
Germany (DE)
Freie Universität Berlin
Germany (DE)
Germany (DE)
Klinikum rechts der Isar
Germany (DE)
mivenion GmbH
Germany (DE)
Freie Universität Berlin
Germany (DE)
How to cite
APA:
Taruttis, A., Wildgruber, M., Kosanke, K., Beziere, N., Licha, K., Haag, R.,... Ntziachristos, V. (2013). Multispectral optoacoustic tomography of myocardial infarction. Photoacoustics, 1(1), 3-8. https://doi.org/10.1016/j.pacs.2012.11.001
MLA:
Taruttis, Adrian, et al. "Multispectral optoacoustic tomography of myocardial infarction." Photoacoustics 1.1 (2013): 3-8.
BibTeX: Download