Modeling long-QT syndromes with iPS cells
Sinnecker D, Goedel A, Dorn T, Dirschinger RJ, Moretti A, Laugwitz KL (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Book Volume: 6
Pages Range: 31-36
Journal Issue: 1
DOI: 10.1007/s12265-012-9416-1
Abstract
The generation of induced pluripotent stem cells (iPSC) from human somatic cells bears the possibility to generate patient-specific stem cell lines which can serve as a theoretically unlimited source of somatic cells carrying the genotype of the patients. Different types of the long-QT syndrome have been studied by analyzing the phenotype of cardiomyocytes generated from patient-specific iPSC lines. Major aspects of the pathophysiology of long-QT syndrome, like prolonged action potentials, arrhythmia, and the effects of pro- and antiarrhythmic drugs could be recapitulated in these cells. In the future, patient-specific iPSC-derived cardiomyocytes might be used to screen for new drugs, to avoid unwanted drug side effects, and to deepen our understanding on the pathophysiology of long-QT syndromes. © 2012 Springer Science+Business Media New York.
Involved external institutions
Germany (DE)How to cite
APA:
Sinnecker, D., Goedel, A., Dorn, T., Dirschinger, R.J., Moretti, A., & Laugwitz, K.-L. (2013). Modeling long-QT syndromes with iPS cells. Journal of Cardiovascular Translational Research, 6(1), 31-36. https://doi.org/10.1007/s12265-012-9416-1
MLA:
Sinnecker, Daniel, et al. "Modeling long-QT syndromes with iPS cells." Journal of Cardiovascular Translational Research 6.1 (2013): 31-36.
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