The estimation of patient-specific cardiac diastolic functions from clinical measurements

Xi J, Lamata P, Niederer S, Land S, Shi W, Zhuang X, Ourselin S, Duckett SG, Shetty AK, Rinaldi CA, Rueckert D, Razavi R, Smith NP (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Medical Image Analysis Elsevier

Book Volume: 17

Pages Range: 133-146

Journal Issue: 2

DOI: 10.1016/j.media.2012.08.001

Abstract

An unresolved issue in patients with diastolic dysfunction is that the estimation of myocardial stiffness cannot be decoupled from diastolic residual active tension (AT) because of the impaired ventricular relaxation during diastole. To address this problem, this paper presents a method for estimating diastolic mechanical parameters of the left ventricle (LV) from cine and tagged MRI measurements and LV cavity pressure recordings, separating the passive myocardial constitutive properties and diastolic residual AT. Dynamic C 1-continuous meshes are automatically built from the anatomy and deformation captured from dynamic MRI sequences. Diastolic deformation is simulated using a mechanical model that combines passive and active material properties. The problem of non-uniqueness of constitutive parameter estimation using the well known Guccione law is characterized by reformulation of this law. Using this reformulated form, and by constraining the constitutive parameters to be constant across time points during diastole, we separate the effects of passive constitutive properties and the residual AT during diastolic relaxation. Finally, the method is applied to two clinical cases and one control, demonstrating that increased residual AT during diastole provides a potential novel index for delineating healthy and pathological cases. © 2012 Elsevier B.V.

Involved external institutions

University of Oxford GB United Kingdom (GB) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) University College London (UCL) GB United Kingdom (GB) King’s College London GB United Kingdom (GB)

How to cite

APA:

Xi, J., Lamata, P., Niederer, S., Land, S., Shi, W., Zhuang, X.,... Smith, N.P. (2013). The estimation of patient-specific cardiac diastolic functions from clinical measurements. Medical Image Analysis, 17(2), 133-146. https://doi.org/10.1016/j.media.2012.08.001

MLA:

Xi, Jiahe, et al. "The estimation of patient-specific cardiac diastolic functions from clinical measurements." Medical Image Analysis 17.2 (2013): 133-146.

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