Spatio-temporal pharmacokinetic model based registration of 4D PET neuroimaging data
Jiao J, Searle GE, Tziortzi AC, Salinas CA, Gunn RN, Schnabel JA (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 84
Pages Range: 225-235
DOI: 10.1016/j.neuroimage.2013.08.031
Abstract
In dynamic positron emission tomography (PET) neuroimaging studies, where scan durations often exceed 1h, registration of motion-corrupted dynamic PET images is necessary in order to maintain the integrity of the physiological, pharmacological, or biochemical information derived from the tracer kinetic analysis of the scan. In this work, we incorporate a pharmacokinetic model, which is traditionally used to analyse PET data following any registration, into the registration process itself in order to allow for a groupwise registration of the temporal time frames. The new method is shown to achieve smaller registration errors and improved kinetic parameter estimates on validation data sets when compared with image similarity based registration approaches. When applied to measured clinical data from 10 healthy subjects scanned with [11C]-(+)-PHNO (a dopamine D3/D2 receptor tracer), it reduces the intra-class variability on the receptor binding outcome measure, further supporting the improvements in registration accuracy. Our method incorporates a generic tracer kinetic model which makes it applicable to different PET radiotracers to remove motion artefacts and increase the integrity of dynamic PET studies. © 2013 Elsevier Inc.
Involved external institutions
United Kingdom (GB)How to cite
APA:
Jiao, J., Searle, G.E., Tziortzi, A.C., Salinas, C.A., Gunn, R.N., & Schnabel, J.A. (2014). Spatio-temporal pharmacokinetic model based registration of 4D PET neuroimaging data. NeuroImage, 84, 225-235. https://doi.org/10.1016/j.neuroimage.2013.08.031
MLA:
Jiao, Jieqing, et al. "Spatio-temporal pharmacokinetic model based registration of 4D PET neuroimaging data." NeuroImage 84 (2014): 225-235.
BibTeX: Download