Bi-directional x-ray phase-contrast mammography

Scherer K, Birnbacher L, Chabior M, Herzen J, Mayr D, Grandl S, Sztrokay-Gaul A, Hellerhoff K, Bamberg F, Pfeiffer F (2014)

Publication Type: Journal article

Publication year: 2014

Journal

PLoS ONE Public Library of Science

Book Volume: 9

Article Number: e93502

Journal Issue: 5

DOI: 10.1371/journal.pone.0093502

Abstract

Phase-contrast x-ray imaging is a promising improvement of conventional absorption-based mammography for early tumor detection. This potential has been demonstrated recently, utilizing structured gratings to obtain differential phase and darkfield scattering images. However, the inherently anisotropic imaging sensitivity of the proposed mono-directional approach yields only insufficient diagnostic information, and has low diagnostic sensitivity to highly oriented structures. To overcome these limitations, we present a two-directional x-ray phase-contrast mammography approach and demonstrate its advantages by applying it to a freshly dissected, cancerous mastectomy breast specimen. We illustrate that the two-directional scanning procedure overcomes the insufficient diagnostic value of a single scan, and reliably detects tumor structures, independently from their orientation within the breast. Our results indicate the indispensable diagnostic necessity and benefit of a multi-directional approach for x-ray phase-contrast mammography. © 2014 Scherer et al.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH (HZG) DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE)

How to cite

APA:

Scherer, K., Birnbacher, L., Chabior, M., Herzen, J., Mayr, D., Grandl, S.,... Pfeiffer, F. (2014). Bi-directional x-ray phase-contrast mammography. PLoS ONE, 9(5). https://doi.org/10.1371/journal.pone.0093502

MLA:

Scherer, Kai, et al. "Bi-directional x-ray phase-contrast mammography." PLoS ONE 9.5 (2014).

BibTeX: Download