Multispectral optoacoustic tomography at 64, 128, and 256 channels

Dima A, Burton NC, Ntziachristos V (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Journal of Biomedical Optics Society of Photo-optical Instrumentation Engineers (SPIE)

Book Volume: 19

Article Number: 036021

Journal Issue: 3

DOI: 10.1117/1.JBO.19.3.036021

Abstract

Optoacoustic (photoacoustic) imaging has already showcased the capacity to offer high-resolution small animal visualization in vivo in a variety of cancer, cardiovascular, or neuroimaging applications. In particular, multispectral optoacoustic tomography (MSOT) has shown imaging along the spectral and the time dimensions, enabling sensing of multiple molecules over time and, more recently, in real time. Furthermore, cross-sectional imaging of at least 20 mm diameter has been showcased in vivo in animals and humans using 64-element curved transducers placed along a single curved line. Herein, we investigated the imaging improvements gained by utilizing a larger number of detectors and inquired whether more detectors will result in measurable image quality improvements. For this reason, we implemented MSOT using 64-, 128-, and 256-element transducers and imaged the same phantoms and animals under similar conditions. Further, corroborated by numerical simulation analysis, our findings quantify the improvements in resolution and overall image quality for the increasing number of detectors used pointing to significant improvements in image quality for the 256 detector array, over 64 or 128 detectors. © 2014 Society of Photo-Optical Instrumentation Engineers.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) iThera Medical GmbH DE Germany (DE)

How to cite

APA:

Dima, A., Burton, N.C., & Ntziachristos, V. (2014). Multispectral optoacoustic tomography at 64, 128, and 256 channels. Journal of Biomedical Optics, 19(3). https://dx.doi.org/10.1117/1.JBO.19.3.036021

MLA:

Dima, Alexander, Neal C. Burton, and Vasilis Ntziachristos. "Multispectral optoacoustic tomography at 64, 128, and 256 channels." Journal of Biomedical Optics 19.3 (2014).

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