Video-rate optical flow corrected intraoperative functional fluorescence imaging

Koch M, Glatz J, Ermolayev V, De Vries EGE, Van Dam GM, Englmeier KH, Ntziachristos V (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Journal of Biomedical Optics Society of Photo-optical Instrumentation Engineers (SPIE)

Book Volume: 19

Article Number: 046012

Journal Issue: 4

DOI: 10.1117/1.JBO.19.4.046012

Abstract

Intraoperative fluorescence molecular imaging based on targeted fluorescence agents is an emerging approach to improve surgical and endoscopic imaging and guidance. Short exposure times per frame and implementation at video rates are necessary to provide continuous feedback to the physician and avoid motion artifacts. However, fast imaging implementations also limit the sensitivity of fluorescence detection. To improve on detection sensitivity in video rate fluorescence imaging, we considered herein an optical flow technique applied to texture-rich color images. This allows the effective accumulation of fluorescence signals over longer, virtual exposure times. The proposed correction scheme is shown to improve signal-to-noise ratios both in phantom experiments and in vivo tissue imaging. © 2014 Society of Photo-Optical Instrumentation Engineers.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) University of Groningen / Rijksuniversiteit Groningen NL Netherlands (NL)

How to cite

APA:

Koch, M., Glatz, J., Ermolayev, V., De Vries, E.G.E., Van Dam, G.M., Englmeier, K.-H., & Ntziachristos, V. (2014). Video-rate optical flow corrected intraoperative functional fluorescence imaging. Journal of Biomedical Optics, 19(4). https://doi.org/10.1117/1.JBO.19.4.046012

MLA:

Koch, Maximilian, et al. "Video-rate optical flow corrected intraoperative functional fluorescence imaging." Journal of Biomedical Optics 19.4 (2014).

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