Ultrawideband reflection-mode optoacoustic mesoscopy

Omar M, Soliman D, Gateau J, Ntziachristos V (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Optics Letters Optical Society of America

Book Volume: 39

Pages Range: 3911-3914

Journal Issue: 13

DOI: 10.1364/OL.39.003911

Abstract

We developed a reflection-mode optoacoustic mesoscopy system, based on raster-scanning of a custom designed spherically focused ultrasound detector, enabling seamless epi-illumination of the volume imaged. We study the performance of acoustic-resolution mesoscopy operating at an ultrawideband bandwidth of 20-180 MHz. i.e., a frequency band spreading over virtually an order of magnitude. Using tomographic reconstruction we showcase previously unreported, to our knowledge, axial resolutions of 4 μm and transverse resolutions of 18 μm reaching depths of up to 5 mm. We further investigate the frequency-dependence of features seen on the images to understand the implications of ultrawideband measurements. We show the overall imaging performance and the frequency ranges that contribute to observable resolution improvements from phantoms and animals. © 2014 Optical Society of America.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) PSL Research University / Université de recherche Paris Sciences et Lettres FR France (FR)

How to cite

APA:

Omar, M., Soliman, D., Gateau, J., & Ntziachristos, V. (2014). Ultrawideband reflection-mode optoacoustic mesoscopy. Optics Letters, 39(13), 3911-3914. https://doi.org/10.1364/OL.39.003911

MLA:

Omar, Murad, et al. "Ultrawideband reflection-mode optoacoustic mesoscopy." Optics Letters 39.13 (2014): 3911-3914.

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