Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature

Lutzweiler C, Meier R, Rummeny E, Ntziachristos V, Razansky D (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Optics Letters Optical Society of America

Book Volume: 39

Pages Range: 4061-4064

Journal Issue: 14

DOI: 10.1364/OL.39.004061

Abstract

We interrogated whether optoacoustic tomography could be employed to study blood functional parameters and biodistribution of injected fluorescent agents in humans. Using a multichannel scanner at a frame rate of 10 images per second, we obtained cross-sectional images of the human finger in real time, before and after the administration of indocyanine green. We demonstrated that multispectral optoacoustic tomography can sense fast flow kinetics and resolve spatiotemporal characteristics of a common fluorochrome in human vasculature at clinically relevant concentrations. We further register ICG images with oxygen saturation maps and anatomical views of the proximal interphalangeal joint of a healthy volunteer. © 2014 Optical Society of America.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Lutzweiler, C., Meier, R., Rummeny, E., Ntziachristos, V., & Razansky, D. (2014). Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature. Optics Letters, 39(14), 4061-4064. https://dx.doi.org/10.1364/OL.39.004061

MLA:

Lutzweiler, Christian, et al. "Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature." Optics Letters 39.14 (2014): 4061-4064.

BibTeX: Download