Estimation of optoacoustic contrast agent concentration with self-calibration blind logarithmic unmixing
Dean-Ben XL, Buehler A, Razansky D, Ntziachristos V (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 59
Pages Range: 4785-4797
Journal Issue: 17
DOI: 10.1088/0031-9155/59/17/4785
Abstract
Chromophore quantification in optoacoustic tomography is challenging due to signal contributions from strongly absorbing background tissue chromophores and the depth-dependent light attenuation. Herein we present a procedure capable of correcting for wavelength-dependent light fluence variations using a logarithmic representation of the images taken at different wavelengths assisted with a blind unmixing approach. It is shown that the serial expansion of the logarithm of an optoacoustic image contains a term representing the ratio between absorption of the probe of interest and other background components. Under assumptions of tissue-like background absorption variations, this term can be readily isolated with an unmixing algorithm, attaining quantitative maps of photo-absorbing agent distribution. © 2014 Institute of Physics and Engineering in Medicine.
Involved external institutions
Germany (DE)How to cite
APA:
Dean-Ben, X.L., Buehler, A., Razansky, D., & Ntziachristos, V. (2014). Estimation of optoacoustic contrast agent concentration with self-calibration blind logarithmic unmixing. Physics in Medicine and Biology, 59(17), 4785-4797. https://dx.doi.org/10.1088/0031-9155/59/17/4785
MLA:
Dean-Ben, X. Luis, et al. "Estimation of optoacoustic contrast agent concentration with self-calibration blind logarithmic unmixing." Physics in Medicine and Biology 59.17 (2014): 4785-4797.
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