Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases: A retrospective analysis of 303 patients
Rief H, Muley T, Bruckner T, Welzel T, Rieken S, Bischof M, Lindel K, Combs SE, Debus J (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 190
Pages Range: 59-63
Journal Issue: 1
DOI: 10.1007/s00066-013-0431-1
Abstract
Background and purpose: For palliative care of spinal bone metastases, stability assessment is of crucial importance. Pathological fractures, instability-related patient immobility and the extent of bone metastasis have been reported to affect patient outcome and these parameters have therefore been used for treatment stratification. We report on stability-dependent fracture and survival rates in over 300 non-small cell lung cancer (NSCLC) patients. Materials and methods: Data from 303 patients with 868 osteolytic metastases treated with radiotherapy (RT) between 2000 and 2012 were evaluated retrospectively. Results: In NSCLC patients with bone metastases only, the retrospective 6- and 12-month overall survival (OS) rates were 76.7 and 47.2 %, respectively. In patients with additional non-bone distant metastases, these values were 60.0 and 34.0 %, respectively. Survival rates were significantly lower in patients with multiple bone metastases and in those suffering pathological fractures (p = 0.017). No significant impact of histological type, location of spinal lesions or treatment regime was detected. Furthermore, stability assessment revealed no influence of vertebral column stability on patient outcome (p = 0.739). Conclusion: Our analysis demonstrated a correlation between the pathological fractures of bone lesions, the number of bone metastases, additional distant metastases and survival. The results offer a rationale for future prospective investigations. © 2013 Springer Heidelberg Berlin.
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APA:
Rief, H., Muley, T., Bruckner, T., Welzel, T., Rieken, S., Bischof, M.,... Debus, J. (2014). Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases: A retrospective analysis of 303 patients. Strahlentherapie und Onkologie, 190(1), 59-63. https://dx.doi.org/10.1007/s00066-013-0431-1
MLA:
Rief, H., et al. "Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases: A retrospective analysis of 303 patients." Strahlentherapie und Onkologie 190.1 (2014): 59-63.
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