Intra-individual comparison of 18F-FET and 18F-DOPA in PET imaging of recurrent brain tumors
Kratochwil C, Combs SE, Leotta K, Afshar-Oromieh A, Rieken S, Debus J, Haberkorn U, Giesel FL (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 16
Pages Range: 434-440
Journal Issue: 3
Abstract
BackgroundBoth 18F-fluorodihydroxyphenylalanine ( 18F-DOPA) and 18F-fluoroethyltyrosine (18F-FET) have already been used successfully for imaging of brain tumors. The aim of this study was to evaluate differences between these 2 promising tracers to determine the consequences for imaging protocols and the interpretation of findings.MethodsForty minutes of dynamic PET imaging were performed on 2 consecutive days with both 18F-DOPA and 18F-FET in patients with recurrent low-grade astrocytoma (n = 8) or high-grade glioblastoma (n = 8). Time-activity-curves (TACs), standardized uptake values (SUVs) and compartment modeling of both tracers were analyzed, respectively.ResultsThe TAC of DOPA-PET peaked at 8 minutes p.i. with SUV 5.23 in high-grade gliomas and 10 minutes p.i. with SUV 4.92 in low-grade gliomas. FET-PET peaked at 9 minutes p.i. with SUV 3.17 in high-grade gliomas and 40 minutes p.i. with SUV 3.24 in low-grade gliomas. Neglecting the specific uptake of DOPA into the striatum, the tumor-to-brain and tumor-to-blood ratios were higher for DOPA-PET. Kinetic modeling demonstrated a high flow constant k1 (mL/ccm/min), representing cellular internalization through AS-transporters, for DOPA in both high-grade (k1 = 0.59) and low-grade (k1 = 0.55) tumors, while lower absolute values and a relevant dependency from tumor-grading (high-grade k1 = 0.43; low-grade k1 = 0.33) were observed with FET.ConclusionsDOPA-PET demonstrates superior contrast ratios for lesions outside the striatum, but SUVs do not correlate with grading. FET-PET can provide additional information on tumor grading and benefits from lower striatal uptake but presents lower contrast ratios and requires prolonged imaging if histology is not available in advance due to a more variable time-to-peak. © 2013 The Author(s).
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Germany (DE)How to cite
APA:
Kratochwil, C., Combs, S.E., Leotta, K., Afshar-Oromieh, A., Rieken, S., Debus, J.,... Giesel, F.L. (2014). Intra-individual comparison of 18F-FET and 18F-DOPA in PET imaging of recurrent brain tumors. Neuro-Oncology, 16(3), 434-440. https://doi.org/10.1093/neuonc/not199
MLA:
Kratochwil, Clemens, et al. "Intra-individual comparison of 18F-FET and 18F-DOPA in PET imaging of recurrent brain tumors." Neuro-Oncology 16.3 (2014): 434-440.
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