Consistent and robust 4D whole-brain segmentation: Application to traumatic brain injury

Ledig C, Shi W, Makropoulos A, Koikkalainen J, Heckemann RA, Hammers A, Lötjönen J, Tenovuo O, Rueckert D (2014)

Publication Type: Conference contribution

Publication year: 2014

Publisher: Institute of Electrical and Electronics Engineers Inc.

Pages Range: 673-676

Conference Proceedings Title: 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014

Event location: Beijing, CHN

ISBN: 9781467319591

DOI: 10.1109/isbi.2014.6867960

Abstract

We propose a consistent approach to automatically segmenting longitudinal magnetic resonance scans of pathological brains. Using symmetric intra-subject registration, we align corresponding scans. In an expectation-maximization framework we exploit the availability of probabilistic segmentation estimates to perform a symmetric intensity normalisation. We introduce a novel technique to perform symmetric differential bias correction for images in presence of pathologies. To achieve a consistent multi-time-point segmentation, we propose a patch-based coupling term using a spatially and temporally varying Markov random field. We demonstrate the superior consistency of our method by segmenting repeat scans into 134 regions. Furthermore, the approach has been applied to segment baseline and six month follow-up scans from 56 patients who have sustained traumatic brain injury (TBI). We find significant correlations between regional atrophy rates and clinical outcome: Patients with poor outcome showed a much higher thalamic atrophy rate (4.9 ± 3.4%) than patients with favourable outcome (0.6 ± 1.9%).

Involved external institutions

Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) VTT Technical Research Centre of Finland FI Finland (FI) University of Gothenburg / Göteborgs universitet SE Sweden (SE) Turku University Hospital / Turun yliopistollinen keskussairaala (TYKS) FI Finland (FI)

How to cite

APA:

Ledig, C., Shi, W., Makropoulos, A., Koikkalainen, J., Heckemann, R.A., Hammers, A.,... Rueckert, D. (2014). Consistent and robust 4D whole-brain segmentation: Application to traumatic brain injury. In 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 (pp. 673-676). Beijing, CHN: Institute of Electrical and Electronics Engineers Inc..

MLA:

Ledig, Christian, et al. "Consistent and robust 4D whole-brain segmentation: Application to traumatic brain injury." Proceedings of the 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014, Beijing, CHN Institute of Electrical and Electronics Engineers Inc., 2014. 673-676.

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