Extended boundary shift integral

Lötjönen J, Ledig C, Koikkalainen J, Wolz R, Thurfjell L, Soininen H, Ourselin S, Rueckert D (2014)

Publication Type: Conference contribution

Publication year: 2014

Publisher: Institute of Electrical and Electronics Engineers Inc.

Pages Range: 854-857

Conference Proceedings Title: 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014

Event location: Beijing, CHN

ISBN: 9781467319591

DOI: 10.1109/isbi.2014.6868005

Abstract

The boundary shift integral (BSI) is a widely used method for measuring atrophy rate, dynamic changes of the gray-matter and cerebrospinal fluid boundaries in magnetic resonance images. BSI is based on intensity differences on this boundary region. This work extends the method in two respects: 1) Instead of using only intensity information on the boundary region, a probabilistic approach is proposed in which also other characteristics of the boundary region can be used. 2) The use of the probabilistic model enables to measure changes between any structures or combination of structures in the image. The performance of the extended BSI is verified against standard BSI in the ADNI and AIBL cohorts. The area-under-the-curve is clearly above 90 % in both cohorts when comparing the classification between cognitively normal and Alzheimer's disease groups. The accuracies of the extended BSI were higher than the standard BSI between these groups.

Involved external institutions

VTT Technical Research Centre of Finland FI Finland (FI) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) Kuopio University Hospital / Pohjois-Savon sairaanhoitopiiri FI Finland (FI) University College London (UCL) GB United Kingdom (GB)

How to cite

APA:

Lötjönen, J., Ledig, C., Koikkalainen, J., Wolz, R., Thurfjell, L., Soininen, H.,... Rueckert, D. (2014). Extended boundary shift integral. In 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 (pp. 854-857). Beijing, CHN: Institute of Electrical and Electronics Engineers Inc..

MLA:

Lötjönen, Jyrki, et al. "Extended boundary shift integral." Proceedings of the 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014, Beijing, CHN Institute of Electrical and Electronics Engineers Inc., 2014. 854-857.

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