Impact of image-based motion correction on dopamine D3/D2 receptor occupancy—comparison of groupwise and frame-by-frame registration approaches
Jiao J, Searle GE, Schnabel JA, Gunn RN (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 2
Pages Range: 1-15
Article Number: 15
Journal Issue: 1
DOI: 10.1186/s40658-015-0117-0
Abstract
Background: Image registration algorithms are frequently used to align the reconstructed brain PET frames to remove subject head motion. However, in occupancy studies, this is a challenging task where competitive binding of a drug can further reduce the available signal for registration. The purpose of this study is to evaluate two kinds of algorithms—a conventional frame-by-frame (FBF) registration and a recently introduced groupwise image registration (GIR), for motion correction of a dopamine D3/D2 receptor occupancy study. Methods: The FBF method co-registers all the PET frames to a common reference based on normalised mutual information as the spatial similarity. The GIR method incorporates a pharmacokinetic model and conducts motion correction by maximising a likelihood function iteratively on tracer kinetics and subject motion. Data from eight healthy volunteers scanned with [11C]-(+)-PHNO pre- and post-administration of a range of doses of the D3 antagonist GSK618334 were used to compare the motion correction performance. Results: The groupwise registration achieved improved motion correction results, both by visual inspection of the dynamic PET data and by the reduction of the variability in the outcome measures, and required no additional steps to exclude unsuccessfully realigned PET data for occupancy modelling as compared to frame-by-frame registration. Furthermore, for the groupwise method, the resultant binding potential estimates had reduced variation and bias for individual scans and improved half maximal effective concentration (EC
Involved external institutions
United Kingdom (GB)How to cite
APA:
Jiao, J., Searle, G.E., Schnabel, J.A., & Gunn, R.N. (2015). Impact of image-based motion correction on dopamine D3/D2 receptor occupancy—comparison of groupwise and frame-by-frame registration approaches. EJNMMI Physics, 2(1), 1-15. https://dx.doi.org/10.1186/s40658-015-0117-0
MLA:
Jiao, Jieqing, et al. "Impact of image-based motion correction on dopamine D3/D2 receptor occupancy—comparison of groupwise and frame-by-frame registration approaches." EJNMMI Physics 2.1 (2015): 1-15.
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