Phthalocyanine photosensitizers as contrast agents for in vivo photoacoustic tumor imaging

Attia ABE, Balasundaram G, Driessen W, Ntziachristos V, Olivo M (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Biomedical Optics Express Optical Society of America

Book Volume: 6

Pages Range: 591-598

Journal Issue: 2

DOI: 10.1364/BOE.6.000591

Abstract

There is a need for contrast agents for non-invasive diagnostic imaging of tumors. Herein, Multispectral Optoacoustic Tomography (MSOT) was employed to evaluate phthalocyanines commonly used in photodynamic therapy as photoacoustic contrast agents. We studied the photoacoustic activity of three water-soluble phthalocyanine photosensitizers: phthalocyanine tetrasulfonic acid (PcS4), Zn(II) phthalocyanine tetrasulfonic acid (ZnPcS4) and Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) in phantom and in tumor-bearing mice to investigate the biodistribution and fate of the phthalocyanines in the biological tissues. PcS4 was observed to grant good contrast between the different reticuloendothelial organs and accumulate in the tumor within an hour of post-administration. ZnPcS4 and AlPcS4 offered little contrast in photoacoustic signals between the organs. PcS4 is a promising photoacoustic contrast agent and can be exploited as a photodiagnostic agent.

Involved external institutions

Singapore Bioimaging Consortium (SBIC) SG Singapore (SG) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Attia, A.B.E., Balasundaram, G., Driessen, W., Ntziachristos, V., & Olivo, M. (2015). Phthalocyanine photosensitizers as contrast agents for in vivo photoacoustic tumor imaging. Biomedical Optics Express, 6(2), 591-598. https://doi.org/10.1364/BOE.6.000591

MLA:

Attia, Amalina Bte Ebrahim, et al. "Phthalocyanine photosensitizers as contrast agents for in vivo photoacoustic tumor imaging." Biomedical Optics Express 6.2 (2015): 591-598.

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