Mass density measurement of mineralized tissue with grating-based X-Ray phase tomography

Gradl R, Zanette I, Ruiz-Yaniz M, Dierolf M, Rack A, Zaslansky P, Pfeiffer F (2016)

Publication Type: Journal article

Publication year: 2016

Journal

PLoS ONE Public Library of Science

Book Volume: 11

Article Number: e0167797

Journal Issue: 12

DOI: 10.1371/journal.pone.0167797

Abstract

Establishing the mineral content distribution in highly mineralized tissues, such as bones and teeth, is fundamental in understanding a variety of structural questions ranging from studies of the mechanical properties to improved pathological investigations. However, nondestructive, volumetric and quantitative density measurements of mineralized samples, some of which may extend several mm in size, remain challenging. Here, we demonstrate the potential of grating-based x-ray phase tomography to gain insight into the three-dimensional mass density distribution of tooth tissues in a non-destructive way and with a sensitivity of 85 mg/cm3 . Density gradients of 13 - 19% over 1 - 2 mm within typical samples are detected, and local variations in density of 0.4 g/cm3 on a length scale of 0.1 mm are revealed. This method proves to be an excellent quantitative tool for investigations of subtle differences in mineral content of mineralized tissues that can change following treatment or during ageing and healing.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) European Synchrotron Radiation Facility (ESRF) FR France (FR) Charité - Universitätsmedizin Berlin DE Germany (DE)

How to cite

APA:

Gradl, R., Zanette, I., Ruiz-Yaniz, M., Dierolf, M., Rack, A., Zaslansky, P., & Pfeiffer, F. (2016). Mass density measurement of mineralized tissue with grating-based X-Ray phase tomography. PLoS ONE, 11(12). https://doi.org/10.1371/journal.pone.0167797

MLA:

Gradl, Regine, et al. "Mass density measurement of mineralized tissue with grating-based X-Ray phase tomography." PLoS ONE 11.12 (2016).

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