Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography-x-ray computed tomography

Ma X, Prakash J, Ruscitti F, Glasl S, Stellari FF, Villetti G, Ntziachristos V (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Journal of Biomedical Optics Society of Photo-optical Instrumentation Engineers (SPIE)

Book Volume: 21

Article Number: 015009

Journal Issue: 1

DOI: 10.1117/1.JBO.21.1.015009

Abstract

Nuclear imaging plays a critical role in asthma research but is limited in its readings of biology due to the short-lived signals of radio-isotopes. We employed hybrid fluorescence molecular tomography (FMT) and x-ray computed tomography (XCT) for the assessment of asthmatic inflammation based on resolving cathepsin activity and matrix metalloproteinase activity in dust mite, ragweed, and Aspergillus species-challenged mice. The reconstructed multimodal fluorescence distribution showed good correspondence with ex vivo cryosection images and histological images, confirming FMT-XCT as an interesting alternative for asthma research.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) University of Parma / Università degli Studi di Parma IT Italy (IT) Chiesi Farmaceutici S.p.A. IT Italy (IT)

How to cite

APA:

Ma, X., Prakash, J., Ruscitti, F., Glasl, S., Stellari, F.F., Villetti, G., & Ntziachristos, V. (2016). Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography-x-ray computed tomography. Journal of Biomedical Optics, 21(1). https://doi.org/10.1117/1.JBO.21.1.015009

MLA:

Ma, Xiaopeng, et al. "Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography-x-ray computed tomography." Journal of Biomedical Optics 21.1 (2016).

BibTeX: Download