Combined label-free optical and optoacoustic imaging of model organisms at mesoscopy and microscopy resolutions
Soliman D, Tserevelakis GJ, Omar M, Ntziachristos V (2016)
Publication Type: Conference contribution
Publication year: 2016
Journal
Publisher: SPIE
Book Volume: 9708
Conference Proceedings Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Event location: San Francisco, CA, USA
ISBN: 9781628419429
DOI: 10.1117/12.2208861
Abstract
We present a multi-scale imaging system that integrates five optoacoustic and multi-photon modalities into the same device. The hybrid microscope offers a unique zoom-in ability by allowing for optoacoustic microscopy and mesoscopy scans of the sample within the same imaging framework. Furthermore, by combining several label-free modalities, we are able to visualize a broad range of anatomical features, taking advantage of their complementary contrast mechanisms. We characterize the spatial resolution and relative orientation of the different sub-modalities and demonstrate the system's performance by the imaging of several model organisms ex vivo. The presented ability to dynamically vary scanning volume and resolution together with its multi-contrast and label-free imaging capabilities make the hybrid microscope a promising tool for comprehensive biological imaging.
Involved external institutions
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Foundation for Research and Technology-Hellas (FORTH) / Ίδρυμα Τεχνολογίας και Έρευνας
Greece (GR)
Germany (DE)
Foundation for Research and Technology-Hellas (FORTH) / Ίδρυμα Τεχνολογίας και Έρευνας
Greece (GR)
How to cite
APA:
Soliman, D., Tserevelakis, G.J., Omar, M., & Ntziachristos, V. (2016). Combined label-free optical and optoacoustic imaging of model organisms at mesoscopy and microscopy resolutions. In Alexander A. Oraevsky, Lihong V. Wang (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. San Francisco, CA, USA: SPIE.
MLA:
Soliman, Dominik, et al. "Combined label-free optical and optoacoustic imaging of model organisms at mesoscopy and microscopy resolutions." Proceedings of the Photons Plus Ultrasound: Imaging and Sensing 2016, San Francisco, CA, USA Ed. Alexander A. Oraevsky, Lihong V. Wang, SPIE, 2016.
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