Synthesis and evaluation of condensed magnetic nanocrystal clusters with in vivo multispectral optoacoustic tomography for tumour targeting

Sarigiannis Y, Kolokithas-Ntoukas A, Beziere N, Zboril R, Papadimitriou E, Avgoustakis K, Lamprou M, Medrikova Z, Rousalis E, Ntziachristos V, Bakandritsos A (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Biomaterials Elsevier

Book Volume: 91

Pages Range: 128-139

DOI: 10.1016/j.biomaterials.2016.03.015

Abstract

Colloidal clusters of magnetic iron oxide nanocrystals (MIONs), particularly in the condensed pattern (co-CNCs), have emerged as new superstructures to improve further the performance of MIONs in applications pertaining to magnetic manipulation (drug delivery) and magnetic resonance imaging (MRI). Exploitation of the advantages they represent and their establishment in the area of nanomedicine demands a particular set of assets. The present work describes the development and evaluation of MION-based co-CNCs featuring for the first time such assets: High magnetization, as well as magnetic content and moment, high relaxivities (r2 = 400 and r2*=905s-1mMFe-1) and intrinsic loss power (2.3 nH m2 kgFe-1) are combined with unprecedented colloidal stability and structural integrity, stealth and drug-loading properties. The reported nanoconstructs are endowed with additional important features such as cost-effective synthesis and storage, prolonged self-life and biocompatibility. It is finally showcased with in vivo multispectral optoacoustic tomography how these properties culminate in a system suitable for targeting breast cancer and for forceful in vivo manipulation with low magnetic field gradients.

Involved external institutions

University of Patras (UPATRAS) GR Greece (GR) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Palacky University Olomouc / Univerzita Palackého v Olomouci CZ Czech Republic (CZ)

How to cite

APA:

Sarigiannis, Y., Kolokithas-Ntoukas, A., Beziere, N., Zboril, R., Papadimitriou, E., Avgoustakis, K.,... Bakandritsos, A. (2016). Synthesis and evaluation of condensed magnetic nanocrystal clusters with in vivo multispectral optoacoustic tomography for tumour targeting. Biomaterials, 91, 128-139. https://doi.org/10.1016/j.biomaterials.2016.03.015

MLA:

Sarigiannis, Yiannis, et al. "Synthesis and evaluation of condensed magnetic nanocrystal clusters with in vivo multispectral optoacoustic tomography for tumour targeting." Biomaterials 91 (2016): 128-139.

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